A Self-Referencing Detection of Microorganisms Using Surface Enhanced Raman Scattering Nanoprobes in a Test-in-a-Tube Platform

A multiplex self-referencing detection of pathogens using surface enhanced raman scattering nanoprobes with a nano-DEP microfluidic concentrator

Surface Enhanced Raman Scattering of Crystal Violet with Low Concentrations Using Self-Assembled Silver and Gold-Silver Core-Shell Nanoparticles

The active substrates in surface enhanced Raman scattering (SERS) spectroscopy were prepared through self-assembly of nanoparticles on functionalized glasses. Colloidal silver nanoparticles (Ag NPs) were prepared chemically in two different sizes by reduction of AgNO3 using trisodium citrate and sodium borohydride. Gold–silver core–shell nanoparticles were also prepared to compare between the o...

Dual recognition mechanism for bacteria detection using surface enhanced Raman spectroscopic nanoprobes

Anisotropic nanoparticles (i.e., silver nanocubes, gold nanorods) based SERS molecular probe were designed and fabricated for the rapid and specific detection of bacterial targets in a test-in-a-tube platform utilizing a novel dual-recognition mechanism. The probes were synthesized by covalently attaching Raman tags and bacteria-specific antibodies to the surface of silver nanocubes. Specific b...

Detection of Molecular Vibrations of Ciprofloxacin Using Flexible Plasmonic Active Substrates as Surface-Enhanced Raman Scattering (SERS) Biosensors

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Detection of extremely low concentration waterborne pathogen using a multiplexing self-referencing SERS microfluidic biosensor

BACKGROUND It is challenging to achieve ultrasensitive and selective detection of waterborne pathogens at extremely low levels (i.e., single cell/mL) using conventional methods. Even with molecular methods such as ELISA or PCR, multi-enrichment steps are needed which are labor and cost intensive. In this study, we incorporated nano-dielectrophoretic microfluidic device with Surface enhanced Ram...